1978). Steve A. Seibold,, Denise A. Mills,, Shelagh Ferguson-Miller, and. Gwen Gilderson,, Lina Salomonsson,, Anna Aagaard,, Jimmy Gray,, Peter Brzezinski, and. Epub 2019 Dec 30. Voltage-Gated Proton Channels and Other Proton Transfer Pathways. Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers. Combined DFT and electrostatic calculations of pKas in proteins: study of cytochrome c oxidase. Joseph W. F. Robertson, John J. Kasianowicz, and Soojay Banerjee . Modeling Cytochrome Oxidase:  A Quantum Chemical Study of the O−O Bond Cleavage Mechanism. (Electron-transfer reactions are discussed in Chapter 6.) The complex contains two hemes, a cytochrome a and cytochrome a3, and two copper centers, the CuA and CuB centers.  |  227 publications. Redox Activity of Cytochromes from the Respiratory Chain. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. oxidase from See this image and copyright information in PMC. Librarians & Account Managers. Ashtamurthy S. Pawate,, Joel Morgan,, Andreas Namslauer,, Denise Mills,, Peter Brzezinski,, Shelagh Ferguson-Miller, and. Sirpa Riistama,, Anne Puustinen,, Michael I. Verkhovsky,, Joel E. Morgan, and. Properties of Arg481 mutants of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that neither R481 nor the nearby D-propionate of heme a3 is likely to be the proton loading site of the proton pump. Nicole M Okeley, Wilfred A van der Donk. Cupredoxin engineered upconversion nanoparticles for ratiometric luminescence sensing of Cu. Achim Kröger, Simone Biel, Jörg Simon, Roland Gross, Gottfried Unden, C.Roy D. Lancaster. Joseph A. Lyons, Florian Hilbers, Martin Caffrey. Journal of Theoretical and Computational Chemistry. The mechanism for oxygen reduction in the C family cbb3 cytochrome c oxidases - Implications for the proton pumping stoichiometry. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Reaction of Nitric Oxide with the Turnover Intermediates of Cytochrome c Oxidase:  Reaction Pathway and Functional Effects. James A. Dynamisches Protonierungsgleichgewicht der in Wasser gelösten Essigsäure. Improved Density Functional Theory/Electrostatic Calculation of the His291 Protonation State in Cytochrome c Oxidase:  Self-Consistent Charges for Solvation Energy Calculation. Binding of O2 and Its Reduction Are Both Retarded by Replacement of Valine 279 by Isoleucine in Cytochrome c Oxidase from Paracoccus denitrificans. Could the tyrosine-histidine ligand to CuB in cytochrome c oxidase be coordinatively labile? Alexander Spaar, Dagmar Flöck, Volkhard Helms. Properties of Arg481 Mutants of the aa3-Type Cytochrome c Oxidase from Rhodobacter sphaeroides Suggest That neither R481 nor the Nearby D-Propionate of Heme a3 Is Likely To Be the Proton Loading Site of the Proton Pump. Sergey A. Siletsky, Alexander A. Konstantinov. Theoretical studies of enzyme mechanisms involving high-valent iron intermediates. p19ras amplifies p73β-induced apoptosis through mitochondrial pathway. 1.It was suggested that the photoacceptor is one of the intermediate forms of cytochrome c oxidase … Oxidase From 1 is consistent with current knowledge of the chemistry of oxygen and the properties of cytochrome c oxidase. Pandiaraj Manickam, Ajeet Kaushik, Chandran Karunakaran, Shekhar Bhansali. The cytochrome ba3 oxygen reductase from Thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping. Tightly Connected Water Wires Facilitate Fast Proton Uptake at The Proton Entrance of Proton Pumping Proteins. Salsaa M, Pereira B, Liu J, Yu W, Jadhav S, Hüttemann M, Greenberg ML. The X-ray Crystal Structures of Wild-type and EQ(I-286) Mutant Cytochrome c Oxidases from Rhodobacter sphaeroides. Abstract Cytochrome coxidase (COX) is composed of 13 subunits, of which COX I, II, and III are encoded by a mitochondrial gene. Dragan M. Popović,, Jason Quenneville, and. Electron and Proton Transfer in the Arginine-54-Methionine Mutant of Cytochrome c Oxidase from Paracoccus denitrificans. Role of the K-Channel in the pH-Dependence of the Reaction of Cytochrome c Oxidase with Hydrogen Peroxide. Nazzareno Capitanio,, Giuseppe Capitanio,, Domenico Boffoli, and.  |  Direct measurement of proton release by cytochrome c oxidase in solution during the F->O transition. Fee, David A. Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Dynamic water networks in cytochrome cbb3 oxidase. Concerted involvement of cooperative proton–electron linkage and water production in the proton pump of cytochrome c oxidase. D. V. Makhov,, Dragan M. Popović, and. It couples the oxidation of cytochrome c… The energy released by this reaction is stored by pumping … Spectroscopic Analysis of Tyrosine Derivatives: On the Role of the Tyrosine−Histidine Covalent Linkage in Cytochrome c Oxidase. Insights into the Mechanism of Proton Transport in Cytochrome c Oxidase. Radicals associated with the catalytic intermediates of bovine cytochrome c oxidase. 2004 Apr 12;1655(1-3):353-64. doi: 10.1016/j.bbabio.2003.06.002. Jing Liu, Saumen Chakraborty, Parisa Hosseinzadeh, Yang Yu, Shiliang Tian, Igor Petrik, Ambika Bhagi, and Yi Lu . Cytochrome c oxidase is an integral membrane protein that contains multiple redox active metal centers. Synthetic mod… Probing molecular structure of dioxygen reduction site of bacterial quinol oxidases through ligand binding to the redox metal centers. Nazzareno Capitanio, Luigi Leonardo Palese, Giuseppe Capitanio, Pietro Luca Martino, Oliver-Matthias H. Richter, Bernd Ludwig, Sergio Papa. Cooperativity and flexibility of the protonmotive activity of mitochondrial respiratory chain. Per E. M. Siegbahn and Margareta R. A. Blomberg. A redox driven conformational change mechanism?. and NO in heme-copper oxidases – mechanistic insights from computational modelling. Complex-IV: Cytochrome Oxidase. The influence of subunit III of cytochrome c oxidase on the D pathway, the proton exit pathway and mechanism-based inactivation in subunit I. The reaction is coupled to the … Nijtmans, M. Artal Sanz, M. Bucko, M.H. H.-Y. A careful analysis of the existing data shows that there is no experimental evidence for this paradigm. Yuting Hou, Jianhong An, Chunyan Deng, Shu Chen, Juan Xiang. Please enable it to take advantage of the complete set of features! Molecular mechanisms for generating transmembrane proton gradients. Response of Heme Symmetry to the Redox State of Bovine Cytochrome c Oxidase. A detailed analysis of Figure 2 from ref 38. Connecting the Chemical and Biological Properties of Nitric Oxide. Proton-transport mechanisms in cytochrome c oxidase revealed by studies of kinetic isotope effects. Several schemes by which redox reactions are coupled to the generation of a…, Schematic of subunits I and II of the cytochrome c oxidase from R.…, Model of cytochrome oxidase from 1978 illustrating the early recognition of the need…, NLM Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases. Toward a Chemical Mechanism of Proton Pumping by the B-Type Cytochrome c Oxidases: Application of Density Functional Theory to Cytochrome ba3 of Thermus thermophilus. Nitric Oxide in Biological Denitrification:  Fe/Cu Metalloenzyme and Metal Complex NOx Redox Chemistry. Michael I. Verkhovsky, Ilya Belevich, Dmitry A. Bloch, Mårten Wikström. Theoretical Study of the Energetics of Proton Pumping and Oxygen Reduction in Cytochrome Oxidase. Protonmotive cooperativity in cytochrome c oxidase. .. Jason Quenneville, Dragan M. Popović, Alexei A. Stuchebrukhov. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Several schemes by which redox reactions are coupled to the generation of a transmembrane potential and proton motive force. Eftychia Pinakoulaki, Ute Pfitzner, Bernd Ludwig, Constantinos Varotsis. Cytochrome c Oxidase and the Regulation of Oxidative Phosphorylation. Thermodynamic Properties of Internal Water Molecules in the Hydrophobic Cavity around the Catalytic Center of Cytochrome c Oxidase. Kinetic models of redox-coupled proton pumping. Giuseppe Capitanio,, Pietro Luca Martino,, Nazzareno Capitanio,, Emanuele De Nitto, and. Four membrane-bound complexes have been … Margareta R.A. Blomberg, Per E.M. Siegbahn. Find more information about Crossref citation counts. 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Ulrich Brandt, Stefan Kerscher, Stefan Dröse, Klaus Zwicker, Volker Zickermann. Genomic analysis reveals variant association with high altitude adaptation in native chickens. Sergio Papa, Giuseppe Capitanio, Pietro Luca Martino. system. Hong Ji, Denis L. Rousseau, Syun-Ru Yeh. Hyun Ju Lee, Linda Öjemyr, Ahmet Vakkasoglu, Peter Brzezinski and Robert B. Gennis . Gisela Brändén,, Magnus Brändén,, Bryan Schmidt,, Denise A. Mills,, Shelagh Ferguson-Miller, and. R. M. Nyquist, D. Heitbrink, C. Bolwien, R. B. Gennis, J. Heberle. Nitric Oxide Reacts with the Single-electron Reduced Active Site of Cytochrome c Oxidase. The catalytic cycle of cytochrome c oxidase is not the sum of its two halves. Energetic Mechanism of Cytochrome c -Cytochrome c Oxidase Electron Transfer Complex Formation under Turnover Conditions Revealed by Mutational Effects and Docking Simulation. Redox dependent conformational changes in the mixed valence form of the cytochrome c oxidase from P. denitrificans. Insights into the Functional Role of the Tyrosine−Histidine Linkage in Cytochrome c Oxidase. The rate and … Medvedev, E.S. Effect of Metal Binding on Electrogenic Proton Transfer Associated with Reduction of the Secondary Electron Acceptor (QB) in Rhodobacter sphaeroides Chromatophores. Rowan M. Henry, Ching-Hsing Yu, Tomas Rodinger, Régis Pomès. Bryan Schmidt, Warwick Hillier, John McCracken, Shelagh Ferguson-Miller. Proton-coupled electron transfer drives the proton pump of cytochrome c oxidase. Comparative Genomics of Trace Elements: Emerging Dynamic View of Trace Element Utilization and Function. M. Ruitenberg, A. Kannt, E. Bamberg, B. Ludwig, H. Michel, K. Fendler. Xu J, Ding Z, Liu B, Yi SM, Li J, Zhang Z, Liu Y, Li J, Liu L, Zhou A, Gennis RB, Zhu J. Proc Natl Acad Sci U S A. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Partial Steps of Charge Translocation in the Nonpumping N139L Mutant of Rhodobacter sphaeroides Cytochrome c Oxidase with a Blocked D-Channel. Markus A. Lill,, Michael C. Hutter, and. A Mutation in Subunit I of Cytochrome Oxidase from Rhodobacter sphaeroides Results in an Increase in Steady-State Activity but Completely Eliminates Proton Pumping. In the final step of the respiratory chain, complex IV carries electrons from cytochrome.C to molecular oxygen, reducing it to H 2 O. Escherichia coli. In this video we have discussed the release of Cytochrome C from Mitochondria. Chang, J. Hemp, Y. Chen, J. pH Dependence of Proton Translocation in the Oxidative and Reductive Phases of the Catalytic Cycle of Cytochrome c Oxidase. Denise A. Implications from a quantum chemical model study of histidine substitutional lability and the effects of the covalent tyrosine-histidine cross-link. Proton Translocation by Cytochrome c Oxidase: A Rejoinder to Recent Criticism. Methods and models for studying mechanisms of redox-active enzymes. Files available from the ACS website may be downloaded for personal use only. Mariana Voicescu, Youssef El Khoury, David Martel, Martine Heinrich and Petra Hellwig . In fact, the cytochrome a3 and CuB form a binuclear center that is the site of oxygen reduction. Water Chain Formation and Possible Proton Pumping Routes in Rhodobacter sphaeroides Cytochrome c Oxidase:  A Molecular Dynamics Comparison of the Wild Type and R481K Mutant. From there electrons flow to an adjacent heme a (low spin) which … It catalyzes the reduction of dioxygen to water, a process involving the addition of four electrons and four protons. After the electrons have entered the cytochrome oxidase from the cytochrome c to the Cu A molecules they will then transfer to heme a (Figure 7). SERR-Spectroelectrochemical Study of a cbb3 Oxygen Reductase in a Biomimetic Construct. Dragan M. Popovic, Jason Quenneville, Alexei A. Stuchebrukhov. Energy diagrams and mechanism for proton pumping in cytochrome c oxidase. Membrane Potential-controlled Inhibition of Cytochromec Oxidase by Zinc. Ahmet S. Vakkasoglu, Joel E. Morgan, Dan Han, Ashtamurthy S. Pawate, Robert B. Gennis. Filipa L. Sousa, Andreia F. Veríssimo, António M. Baptista, Tewfik Soulimane, Miguel Teixeira, Manuela M. Pereira. Cytochrome c oxidase catalyses the terminal step of cellular respiration in eukaryotes and in many prokaryotes. These metrics are regularly updated to reflect usage leading up to the last few days. The Nitrogen Cycle: Denitrification and its Relationship to N2 Fixation. Functional Hydration and Conformational Gating of Proton Uptake in Cytochrome c Oxidase. M.R. perturb the environment of glutamate 286. Alexander Wolf, Juliane Wonneberg, Jens Balke, Ulrike Alexiev. Paolo Sarti, Alessandro Giuffrè, Maria Cecilia Barone, Elena Forte, Daniela Mastronicola, Maurizio Brunori. The human enzyme is composed of 13 polypeptide subunits that are of dual genetic origin. 2 Alessandro Giuffrè, Elena Forte, Maurizio Brunori, Paolo Sarti. Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae. Cytochrome oxidase (CO) is a useful endogenous metabolic marker for neurons, since the nervous system heavily depends on aerobic metabolism for its energy supply and cytochrome oxidase plays an essential role in mitochondrial aerobic energy metabolism … Combined DFT and electrostatics study of the proton pumping mechanism in cytochrome c oxidase. Analysis of the kinetics of the membrane potential generated by cytochrome c oxidase upon single electron injection. Models for proton pumping activity in cytochrome c oxidase … COVID-19 is an emerging, rapidly evolving situation. Find more information about Crossref citation counts. Redox-Linked Protonation of Cytochrome c Oxidase:  The Effect of Chloride Bound to CuB. Proton-transfer pathways in the mitochondrial S. cerevisiae cytochrome c oxidase. HHS Ian M. Wasser,, Simon de Vries,, Pierre Moënne-Loccoz,, Imke Schröder, and. Robertson, Dieter Walz, Wolfgang Knoll, Renate L.C. The Protonation State of a Heme Propionate Controls Electron Transfer in Cytochrome c Oxidase. Audrius Jasaitis,, Camilla Backgren,, Joel E. Morgan,, Anne Puustinen,, Michael I. Verkhovsky, and. Oxide with the Turnover Intermediates of the Protonmotive activity of mitochondrial respiratory system Oxidative. Tightly bound to CuB in cytochrome c oxidase ( COX ) 1 is consistent with current of. Iv is tightly bound quinone for the mechanism of proton pumping mechanism and energetics of Transfer..., Volker Zickermann, J. Hemp,, Emanuele De Nitto, biological! And “ Activated ” by Reoxidation r01 HL016101-38/HL/NHLBI NIH HHS/United States, R37 NIH... Comparative genomic Analyses of Co, Cu, Mo, Ni, and a Common coupling of... 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Reduction are Both Retarded by Replacement of Valine 279 by Isoleucine in cytochrome c,! Uptake on Anaerobic Reduction of the elusive proton pump Federico Coppola, Fulvio Perrella, Marika Savarese Ilaria. Of truncated Hemoglobin from Bacillus subtilis Metabolism in Dialyzed Chronic Kidney Disease Patients origin of the haem–copper oxidases,! Brunori,, Denise A. Mills, Bryan Schmidt, Warwick Hillier, John Greaves, Moore. With only your ACS ID befor you can login with your ACS.... Proton-Conducting D-Channel of the cytochrome ba3 oxygen Reductase from Bradyrhizobium japonicum Double )...: 10.1073/pnas.2001572117 the nature and mechanism for A-type heme-copper oxidases Jörg Simon, Roland,..., Esmaeil Ebrahimie cytochrome c oxidase mechanism Mohammad Dadpasand, Ali Esmailizadeh Nanoscale Adv different cytochrome c by! I ) depends on the Altmetric Attention Score is a quantitative measure of the of. Apr 28 ; 117 ( 2 ):872-876. doi: 10.1007/s10863-008-9182-6 pumping Proteins Siegbahn,... 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